一架从洛杉矶飞往巴黎的747航班上，搭载了几名不速之客。他们是来自美国军方的科学家，现在正计划带着一具尸体逃离美国。此前，他们在CIA的授意下对疟疾病毒进行研究，旨在开发出适合战争需要的生化武器，最终他们一种神奇的病毒应运而生。被该病毒感染的人其生命力、爆发力以及意志都空前增强，与之相对疼痛感和恐惧心理则降至最低，即使身负重伤他们也能勇往直前，决不退缩。科学家们所带的尸体正携带这种恐怖的病毒。　　飞机在空中遭遇强烈的雷阵雨，剧烈的颠簸将行李舱内的尸体释放出来，并迅速化身为毫无人性、嗜血如命的恐怖僵尸。才从暴风雨的侵袭中舒缓过来的乘客们怎么也没想到，机舱很快将变成充满杀戮的血腥地狱……

In the age of social media, teenagers tell the story that they want people to see, with each video more daring than the next. But in this small town, a series of staged "murder" videos are turning very real.

Aspiring actress, Kia Anderson, is about to learn that the final callback for a horror Feature Film is something more than she could ever of imagined - Something sinister is awaiting for Kia.

Michael (or Fresh as he's well known) is a 12-year-old drug pusher who lives in a crowded house with his cousins and aunt. His father has become a street bum,but still meets with fresh on occasion to play chess. Fresh is rather quiet in a crazy world. Fresh' sister is a junkie who sleeps with the dealers that fresh sells for. As the story progresses Fresh realizes that he doesn't want to sell drugs anymore, he wants revenge.

　　夜幕低垂，一名怀才不遇的电影人开始向朋友讲述一连串令人忐忑的故事，惊魂颤栗的转折也随即出现。