Hamilton, Ohio was a sleepy little town. That is until a covenant of vampires decides to feed there. An upper class illuminati tries to reveal the vampires secrets to everlasting life, but in the meantime the vampires ravage the locals and baffle police. The only one with the power to stop them is one of their own.

　　在莎拉（Sarah）生日那天，她最好的朋友维多利亚（Victoria）给了她一套基因检测试剂盒作为礼物，以便她可以更多地了解家人的血统。但是那天晚上，维多利亚被惨死了。几周后，莎拉敲了敲门，是警察。

When Bosnian-born Aisha and cameraman Elias team up to shoot a documentary on the mysterious disappearance of Aisha's brother, they cross paths with another film crew, who are creating an even more sinister narrative.

In seventeenth century England Lord Whitman wages unending war on what he sees as the ever-present scourge of witchcraft, and many local villagers have suffered at his hands. But one victim uses her occult powers to curse his family, enlisting unknowing help from one of the household.

1979年，罗马梵蒂冈教廷意识到和恶魔撒旦有着莫大关系的一名女婴诞生在纽约，二十年后，距离本世纪还剩最后三天的12月28日，撒旦（加布里埃尔·伯恩 Gabriel Byrne 饰）以一名人类银行家的肉身重现人间，丧失了妻女的前任警察杰瑞克（阿诺·施瓦辛格 Arnold Schwarzenegger 饰）和自己的安保团队受雇于伪装的魔鬼，为其提供保护。不久一名神父冒死狙杀撒旦，不幸失败，他在临死前向布瑞克提出警告。布瑞克与同伴按照神父留下的线索找到了女子克里斯汀（罗宾·汤尼 Robin Tunney 饰），得知她是命中注定要与撒旦结合的女性，如果撒旦能在千禧之夜和克里斯汀发生关系，那就意味着世界的毁灭。布瑞克决定不惜一切代价以人类的身份阻挡撒旦……