Theo Abrams is an ex-Cape Town fireman suffering from severe Post-Traumatic Stress Disorder. Unable to return to work due to the psychological trauma sustained during a failed rescue mission, an increasingly frustrated and volatile Theo's world is rocked when one morning, he wakes up next to his wife's murdered corpse with no recollection of what transpired and all evidence suggesting that he's killed her. When the police label him as the prime suspect, Theo goes on the run, and is soon being hunted by Deputy Chief of Police, Alan Shard, a notoriously ruthless soldier of the law, who is hell-bent on catching Theo as one last act of service before he officially retires. However, when an unknown third party is thrown into the mix, Theo discovers an alarming connection between the sinister forces hunting him in an attempt to silence him permanently for a reason he can't comprehend; and a recent investigation his wife was conducting into a global armament contractor. When connecting the dots becomes a matter of life and death, Theo becomes embroiled in a desperate fight for survival and must figure out who really murdered his wife before a terrifying conspiracy changes the course of a nation forever.

一伙悍匪趁夜袭击了一名年轻女子所在的医院来寻找他们的犯罪证据——残留在女子腿部的一颗子弹。一位受命保护女子的老警察成了此时女子免遭杀害的唯一希望。

这个故事是关于一场权力大战的发生，这场权力大战发生在全球不同地区的无关紧要的，不相关的情节中，以不可预见的方式纠缠在一起，揭开了心灵游戏的神秘面纱。故事将观众带入了一个精湛的大师头脑的游戏，以揭示所涉及的一切的真实本质。它挑战了关于谁是猎人和谁是被猎物的观念。它融合了激动人心的故事和讲故事的商业元素，以提供高辛烷值的演艺人员来吸引所有受众。

十九世纪，罗马尼亚存在着一个人鬼共存的神秘地带――特兰西尼亚古镇。镇上有一支邪恶势力在天黑后统治着该地区，那就是吸血鬼德古拉（理查德?劳斯伯格 Richard Roxburgh 饰）领导下妖魔鬼怪。他们一到日黑就出来大肆杀戮，手段异常残忍。更加恐怖的是，这个队伍在不断壮大中，噬血的科学怪人也不远万里投靠了德古拉。 　　罗马尼亚的天主教在多次征剿失利后，远赴美国请来了吸血鬼猎人范海辛（休?杰克曼 Hugh Jackman 饰）。范海辛带着助手前往特兰西尼亚途中，巧合下救了另一位吸血鬼女猎人――安娜（凯特?贝金赛尔 Kate Beckinsale 饰）。安娜因为家族世代受到德古拉的诅咒而家破人亡，从小练就了一套猎鬼本领。安娜和范海辛一拍即合，共同前往对付德古拉……

百年之前，一系列的连锁巨变摧毁了多数的地球文明，将世界带入了无尽的黑暗时期。剩余的幸存者试图回到过去改变引起这一切毁灭事件的进程。