单亲妈妈Holly为了维持生计，成了一名好莱坞皮卡司机，在车里经营黑市医用品。与此同时，她能否逃脱FBI特工的无情追捕？

　　本片改编自美国家喻户晓的连环杀手“艾德.盖恩”的真实故事，但修改了案发地和凶手的姓名，此片讲述了凶手在他母亲死后由于受不了母亲已经死亡的打击，开始犯下盗墓、谋杀、毁尸、食人和恋尸癖等罪，并开始慢慢走向精神错乱的过程……

　　Double agent Picasso Trigger is assassinated in Paris by double-crossing bad guy Miguel Ortiz. Then Ortiz begins eliminating agents of The Agency who were involved in his brother's death. The Agency (belatedly) springs into action to stop Ortiz' heinous activities. The usual gunplay, romance, and nifty toys with bombs ensue.

A group of homeless misfits must fight for survival when they discover a plot to exterminate every homeless person in the city.