24岁的波士顿大学医学院学生马可夫（Philip Markoff）利用Craigslist广告, 欺骗从事**交易的女子上勾，然后在旅馆中抢劫她们, 甚至残忍的谋杀她们。媒体叫他Craigslist网站杀手, 一连串的案件令警方及社会陷入深深的不安…　　“The Craigslist Killer” follows the dark, mysterious life Philip Markoff (Jake McDorman) conducted online while preparing for a promising future as a doctor and a life of happiness with his fiancée, Megan McAllister (Agnes Bruckner). Seemingly destined for greatness as one of Boston University’s brightest med students, Markoff could do no wrong in the eyes of Megan, his friends, fellow students and professors. But hidden from those close to him was the violent wrath only he and his victims knew — beginning with his alleged April 14, 2009, first-degree murder of a masseuse who advertised her services on Craigslist. When police discover that the brutal killing and a number of other attacks on women were all connected to advertisements placed on Craigslist, their investigation ultimately leads them to Markoff. William Baldwin portrays the lead detective investigating the case.　　Philip Markoff (Jake McDorman) had it all. A straight-A medical student with a beautiful fianc閑 (Agnes Bruckner), Philip had a future others could only envy. But when a masseuse is murdered by a man she meets through an ad she placed on Craigslist, the clues point directly toward Philip, whom the police accuse of leading a secret life where he preys upon young women. William Baldwin costars in this shocking tale of deception and lies, based on the true story that stunned a nation.

　　重案组探员寇派克•麦斯（威廉•鲍德温 William Baldwin 饰）迎来了混乱的一天，先是一大早就被女友芮塔（萨尔玛•海耶克 Salma Hayek 饰）划清界限赶出家门，又因不良记录贷款无望，麦斯因职责所在为在大街上中流弹的律师凯蒂（辛迪•克劳馥 Cindy Crawford 饰）做笔录，岂料对方也是个尖牙利嘴的狠角色。当晚麦斯发现白天的记录不完备，只得赶赴凯蒂家中，居然遇到凯蒂家中爆炸，麦斯与持枪歹徒一番混战救下凯蒂，由此卷入了间谍团伙的追杀。原来凯蒂近期带离的一桩民事案件，涉及一艘船的归属，而该船是国际间谍团伙用于水底窃听的设备，于是遭到团伙追杀。在一流间谍团伙的追杀下，麦斯无法请求支援，只能依靠自己的力量保护凯蒂，并为殉职的同事报仇。

　　盖布丽（安琪拉·琼斯 Angela Jones 饰）的童年里有一段非常可怕的经历，年幼的她曾经在凶杀现场亲眼目睹死尸。这一段奇异的人生经历让盖布丽开始对尸体和死亡产生了好奇之心，这股子好奇随着她年龄的增大越发强烈起来，盖布丽甚至会特意的收藏报纸上的谋杀新闻做成剪报册，时时翻阅温习。　　迈阿密接连发生凶杀案，被害者均是养尊处优的阔太太，而且无不身首异处。这起连环杀人案件很快就吸引了盖布丽的注意，为了能够更加接近命案现场，盖布丽来到了一间专门清理命案现场的保洁公司应聘成为了员工，并且在机缘巧合之下同连环杀人犯（威廉·鲍德温 William Baldwin 饰）有了一面之缘。