Four insomniac med school students are lured into a neuroscience experiment that spirals out of control and must find a way out before it's too late.

特洛伊战争后，奥德修斯与同伴飘泊于茫茫大海，塞壬女妖的以歌声诱惑他们，突然又有飞行的怪兽来袭，船毁人散。醒来之后奥德修斯一行发现自己来到一座死亡之岛，那群怪兽就住在岛上，更有一神秘女子被囚在岛上，原来是冥后珀尔塞福涅……